|
KMID : 0903520090520010022
|
|
Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2009 Volume.52 No. 1 p.22 ~ p.27
|
|
|
Efficacy of Aspirin on Improvement of Peripheral Blood Circulation in Mice
|
|
Yoo Bo-Kyung
Ko Byoung-Seob
Ma Jin-Yeul
Jeon Won-kyung
|
|
|
Abstract
|
|
|
|
An in vivo model for assessing the efficacy of aspirin on the improvement of peripheral circulatory was developed by obtaining the cold-induced peripheral blood flow in mice using laser Doppler flowmetry (LDF) and temperature-controlled chambers. ICR mice (n=6) were placed in a temperature-controlled chamber and anesthetized with 1.5% isoflurane. LDF was used to measure the peripheral blood flow during whole-body warming for 10 min (37℃, baseline) and cooling for 40 min (until 13℃). Peripheral blood flow ratio showed significant difference between baseline and whole-body cooling after a lapse of 20 (0.92±0.20) and 40 min (0.33±0.13, p<0.001). Peripheral blood flows of mice administered aspirin (100 mg/kg) or control substance (saline) were measured. Mean peripheral flow ratio decrement of the hind foot was significantly higher in aspirin (0.23±0.10, p<0.05) than the control substance (0.15±0.04). These findings indicate that wholebody cooling is characterized by peripheral circulatory disturbance, which also influences the efficacy of aspirin in improving the peripheral blood circulation.
|
|
|
KEYWORD
|
|
|
aspirin, cold-induced, in vivo model, laser Doppler flowmetry, peripheral blood flow
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|